The top 25 strikeouts leaders in Colorado high school softball.
| Rank | Player | School | K | BF | IP | Games |
|---|---|---|---|---|---|---|
| 1 | Amaya Cron | Greeley West | 134 | 343 | 71.2 | 12 |
| 2 | Brooke Riofrio | Northridge | 106 | 349 | 72.1 | 13 |
| 3 | Bentley Schiller | Montrose | 106 | 252 | 62 | 11 |
| 4 | Katie Thomas | Severance | 104 | 263 | 56.2 | 10 |
| 5 | Danica Flesner | Valley | 96 | 385 | 76 | 14 |
| 6 | Addison Dalton | Florence | 95 | 195 | 45.1 | 11 |
| 7 | Tia Homedew | Cedaredge | 91 | 291 | 60.2 | 12 |
| 8 | Isabelle Aragon | La Junta | 84 | 277 | 57 | 13 |
| 9 | Johanna Galvan | Eaton | 84 | 280 | 63.1 | 12 |
| 10 | Haley Cross | Wheat Ridge | 83 | 206 | 43.1 | 9 |
| 11 | Laikyn Lanzen | Brighton | 83 | 287 | 61 | 13 |
| 12 | Alyssa Kendrick | Platte Valley | 83 | 319 | 60 | 14 |
| 13 | Carlin Weber | Lamar | 82 | 277 | 57.2 | 11 |
| 14 | Sophee Horovitz | Erie | 78 | 249 | 55.1 | 10 |
| 15 | Emerson Ross | Sterling | 77 | 406 | 74.1 | 14 |
| 16 | Jennisa Hale | Weld Central | 75 | 400 | 71.1 | 12 |
| 17 | Jenna McGinnis | Windsor | 73 | 163 | 41 | 10 |
| 18 | Addison Swenby | Columbine | 71 | 274 | 53.2 | 13 |
| 19 | Olivia McEwen | Widefield | 70 | 235 | 50 | 11 |
| 20 | Hailey Bergman | Conifer | 69 | 232 | 42.2 | 9 |
| 21 | Nora Midness | Centaurus | 68 | 226 | 47.2 | 13 |
| 22 | Julianna Alfaro | Forge Christian | 68 | 205 | 47 | 12 |
| 23 | Paige Bessire | Burlington | 66 | 359 | 58 | 14 |
| 24 | Sidnee Sais | Frederick | 63 | 226 | 51 | 13 |
| 25 | Selah Joiner | Liberty | 63 | 209 | 39.2 | 12 |
